4 research outputs found
In vitro corrosion resistance and in vivo osseointegration testing of new multifunctional beta-type quaternary TiMoZrTa alloys
The present study explores the in vitro and in vivo responses of new multifunctional
quaternary beta-type TiMoZrTa alloys designed for biomedical implantation. The
electrochemical resistance to corrosion of the alloys was investigated in vitro, using linear
potentiodynamic polarization (LPP) and electrochemical impedance spectroscopy (EIS) tests
in acidified physiological saline solution at 37 oC. The pH was adjusted to 4.0 by adding lactic
acid in order to simulate the hypoxia stress condition that may occur in the healing process of
fractures. The biomaterial alloys spontaneously formed a passivation oxide film on their
surfaces, which remained stable for polarizations up to +1.0 VSCE, and became more resistant
with the increased amount of Ta in the alloy composition. The animal tests of the quaternary
Ti-20Mo-7Zr-xTa alloys showed adequate biocompatibility as a tibial implant. Among them,
the 15% Ta-alloy implant showed the best osseointegration according to the results of the
biochemical, histological and computed tomography characterizations, and can be considered
as a potential biomaterial with low elastic modulus (43.6 GPa)
New Ti-6Al-2Nb-2Ta-1Mo alloy as implant biomaterial: in vitro corrosion and in vivo osseointegration evaluations
Over the last decade, new titanium alloys are developed in different areas of
implantology. The aim of this study was to characterize a new Ti-Al-Nb-Ta-Mo based alloy, with
high potential for being used as a biomedical implant. The evaluation of Ti-6Al-2Nb-2Ta-1Mo
was performed both in vitro (by monitoring its corrosion resistance in Hank’s Balanced Salt
Solution, HBSS) and in vivo (by evaluating the osseointegration following rabbit tibia
implantation), by comparison with titanium and Ti-6Al-7Nb alloy. Electrochemical impedance
spectroscopy (EIS) data showed high impedance values for all titanium samples after 1 week
immersion times in HBSS at 37 oC. According to EIS analysis, the corrosion resistance of the Ti-
6Al-2Nb-2Ta-1Mo alloy immersed in HBSS was higher compared to the standard cp-Ti or with
the Ti-6Al-7Nb alloy. In addition, a higher degree of osseointegration was achieved by the Ti-
6Al-2Nb-2Ta-1Mo alloy, thus probing that a higher resistance to electrochemical corrosion
provided enhanced protection to the implant surface against biodegradation, thus positively
affecting the qualitative and quantitative evolution of bone tissue repair
Idiopathic sudden hearing loss: Oxidative status before and after corticoid treatment
The aim of this study was to investigate antioxidant enzyme activities and
lipid peroxidation levels after systemic corticoid therapy (Solu-Medrol,
250mg/day, for 7 days). The effects of corticoid treatment on superoxide
dismutase (SOD) and glutathione peroxidase (GPX) activity were investigated.
Fifteen patients diagnosed with sudden sensorineural hearing loss were
enrolled. Serum markers of oxidative stress were measured using
spectrophotometric methods. In ten cases, the SOD and GPX activities and
malondialdehyde (MDA) serum levels before and after corticoid treatment were
investigated. Corticoid treatment enhanced antioxidant activity by increasing
SOD and GPX activities and decreasing MDA serum levels